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Interferon Gamma Gene Polymorphism as a Biochemical Marker in Egyptian Atopic Patients
Faculty
Medicine
Year:
2009
Type of Publication:
Article
Pages:
292-298
Authors:
Shalaby, S. M, Hussein, Y. M, Ahmad, A. S, Ibrahem, M. M, El Tarhouny, S. A, Elshal, A. S, El Said, M
Journal:
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY ESMON PUBLICIDAD S A
Volume:
19
Research Area:
Allergy; Immunology
ISSN
ISI:000268830100006
Keywords :
Interferon gamma, Polymorphism, Atopic patients
Abstract:
Objectives:The aim of this study was to clarify the role of interferon (IFN) gamma in the diagnosis and follow-up of atopic patients. We genotyped the IFN-gamma polymorphism at position +874 to examine the relationship between serum levels of IFN-gamma and disease severity and the role of IFN-gamma as a biochemical and immunologic marker. Methods: The study population comprised 75 patients suffering from atopic asthma, atopic dermatitis, and allergic rhinitis (25 each), and 25 control participants. Total immunoglobulin (Ig) E and serum IFN-gamma were measured by enzyme-linked immunosorbent assay, the IFN-gamma polymorphism at position +874 was determined by amplification refractory mutation system-polymerase chain reaction, and eosinophil counts were recorded. Results: There was a significant association between genotype and the frequency of the A allele of the +874T/A polymorphism in atopic patients when compared with controls (P<.001). In all 3 groups, there was a significant increase in total IgE levels and eosinophil counts, and a decrease in serum IFN-gamma levels towards the presence of homozygous AA compared with homozygous TT. Conclusions: The IFN-gamma gene polymorphism at position +874 contributes to susceptibility to atopic diseases by decreasing the amount of IFN-gamma. Identification of variants of IFN-gamma gene signalling and its role in the development of atopic diseases provides a focus for the development of novel diagnostic and therapeutic strategies for these diseases.
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