Experimental pathological studiees of some pesticides induced through transplacental transmission in albino Rats

Herbicides were chemicals used for controlling weeds and environmentalundesirable polution resulting from herbicides spraying may lead to bad effects on both human and animals. The aim of the present work was to study the toxic effects of atrazine and glyphosate herbicides on pregnant albino rats and their feti.Seventy female rats were divided into 3 ma i n groups. each of the first and second groups were consisted from 30rats, and both groups were equally subdivided into subgroups A,B and C, which orally received 1/10 LD50 herbicide from 1st to 20th, 8th to 15th and 15th to 20th day of gestationrespectively. The third main group was consisted from 10 rats and kept as control.The lesions in group I (subgroup A,B and C) which received 250 mg/kg B.wt.atrazine were similar. The liver was enlarged, dark red and friable. Microscopically, congestionof hepatic blood vessels, degenerative changes and infilt-ration of portal areas with lymphocytes were observed.Coagulative necrosis, fatty change and fibroblastic proli- feration were noticed in subgroup I-A beside fatty change only in the liver of subgroup I-B. The lungs were enlarged and congested. Focal hepatized areas dark red in calor were seen in subgroup I-