Pharmacological studies on the concurrent use of doxycycline and colistin chickens

Many new drugs have been introduced in veterinary practice, their availability stimulated for their concomit- ant use to achieve maximum effectiveness. Of these drugs concurrent use of doxycycline and colistin for treatment of colibacillosis in chicks whicausing major economlC losses achieved by high morbidity and mortality, loss of body weight and low egg production.The present investigation challenges the in vitro sensitivity of E. coli to doxycycline, colistin and theircombination and in V1VO activity of these drugs against experimentally E. coli infection in chicks theirinfluences on serum constituents and histopathological changes of the treated chicks were considered. The a nvitro sensitivity of E. coli to the concurrent use of colistin and doxycycline was more effective than either colistin or doxycycline alone.Studying the in vivo efficacy of doxycycline, colistinand their combination in controlling experimental E. coliinfection in chicks revealed that both combination of two drugs and doxycycline were highly effective against E. coli infection, reducing the mortality rate, gross pathologicallesions and improving the body weight gain. But combinationMany new drugs have been introduced in veterinary practice, their availability stimulated for their concomit-ant use to achieve maximum effectiveness. Of these drugsconcurrent use of doxycycline and colistin for treatment ofcolibacillosis in chicks which affect poultry industry c a u s i ng major economlC losses achieved by high morbidity and mortality, loss of body weight and low egg production.The present investigationthe in vitrosensitivity of E. coli to doxycycline, colistin and theircombination and in V1VO activity of these drugs againstexperimentally E. coli infection in chicks their influences on serum constituents and histopathologicalchanges of the treated chicks were considered. The a n vitro sensitivity of E. coli to the concurrent use ofcolistin and doxycycline was more effective than either colistin or doxycycline alone. Studying the in vivo efficacy of doxycycline, colistinand their combination in controlling experimental E. coli infection in chicks revealed that both combination of two drugs and doxycycline were highly effective against E. coliinfection, reducing the mortality rate, gross pathological lesions and improving the body weight gain. But combination