Effects of some antimicrobials on the autonomic nervous transmission

The present study was performed to study the possible effects of the antimicrobial drugs; sulphadimidine and cephradine on cholinergic transmission using; directly and indirectly stimulated rat phrenic nerve diaphragm preparation, transmurally stimulatedguinea pig ileum and rabbit sciatic nerve-tibialis anterior muscle.I-Effects on isolated preparationa) Rat phrenic nerve - Hemidiaphrogm preparation, Both drugs significantly (P < 0.05) blocked the twitch responses of indirectly stimulated rat diaphragm.Sulphadimidine (3. 6 and 8 mg/ml) evoked initial stimulatoryeffect of 22.3% ± 7.23,13.08% ± 5.23 and 3% ± 0.72 respectively in theresponse at first minute that was followed by a blocking effect of62.41 % % ± 11.34, 81.18% ± 10.58 and 92.43% ± 6.76 respectively on thecontrol twitch response after 15 minutes.