| Abstract: |
Allopurinol, a structural analog of hypoxanthine, is a potent. inhibitorof xanthine oxidase, it has been used’ extensively for the clinical control nfuric acid production in gout and other forms of hyperuricaemia.In this .work, the author endeavoredto investigate the metabolicdisturbances brought by the di ffcrent doses of the drug (10, 30 and 60 mg/kg B.w./day) and at various times of administration (24 hours, j days, 6days and 9 days), for this study, a 168 rats were subjected to the trial,divided into 6 groups each group 28 rats, each group subdivided into 4subgroups according 10 the periods of administration, the administrationcarried out dai ly, and the rats were sacrificed after 24 hours of the b:;tdose, the bloocl was collected for several assays.Generally, administration of allopurinol results in fall of scrum uricacid within 3-6 days of administration, the significant reduction occurcdafter the 9th day of therapy in the serum of rats received 10 mg/kg B,w./day of the drug, while the reduction begun from the first day of therapy inthe serum of rats administered with 30 and 60 mg/kg B.w./day. So, themagnitude’ of this decrease is dose dependent.Allopurinol had no impairment of iron content, nor incorporationinto hemoglobin.
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