| Abstract: |
The clenrance of amnicillin and furazolidone wereestimated in 12 dairy goats. Six goats were injeoted int-ravenoualy with a single therapeutic dose (5 me/kg bodyweight) of ampicillin, while the other 6 goats were givenfurazolidone orally in a sinele dose (12 mg/kg body weight).Samples of blood were collected just before and 5,I5,30 mln-utes,I,2,3,4,6,8,I2 and 24 hour-s p oat administration. Urineand milk n8.mrles were collected just before and 15,30 minutes and I,2,3,4,6,8,I2 and 24 hoursost administration. The con-centration of both drues in these fJuids, its protein bindinger.r1ogenI)UD crentinine and ur en c Le ar-ane e were esttmatcd ••:?ollowing intravenous inj ec -;;:’021 of ampicillin in e.. doseof 5 mg/xl!, body weiC;h”t, the concentratio”1 of the drug inplasma reRched its maximurr. lev~~l (4.85 pg/ml’ at 5 minutesafter I~nj e c t Lo n , then decrealJed gradually till the 6 th hourpost injention (o.o~ pg/ml).T’ne c~ncentrat.ion of e.mpicillin in ur-Lne after intrav-enoud e.dnt:.n~.!!ftration of the same dose, reached its maxtmumlevel (291047 P3/ml) at the J rd hour then began to decreRReerA-Qually till its minimum concen.trI:4~;ion (J.!I ug/ml) after24 hour post injection
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