Pharmacological properties of some essential amino acids with special references to their sex hormone-like actions

The pharmacological effects of the I!-amino acids; arginine, histidine and methionine were Lnv e s t t.ge.t e d ,Growth influence of the injected amino 8.(’1d8 was detected . The hormone-like acti vi ties and interact5.ons wi, th the sex hormones; testosterone~ oestrogen and progesterone were reported. ~ffects on the i:J,;testj_nal m.ot-1it.xJ. The effects of the L-were investigated on isolated rabbit j e;u.:cum. L-arginine ha4 a dose -related ihhibi tory action. Small doses of acetyl choline and nicotine sti.mulated the Ls o La ted intestine in the presence of arginine. L-methionine exhibited a dose-dependent stimumotility of the nicotini»ed, and atropinized intestinal strip. L-histidine did not affect the motility of the rabbi t j e j unum.