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Synthesis, reactions and biological activity of 2-substituted 3-cyano-4,6-dimethylpyridine derivatives
Faculty
Science
Year:
2009
Type of Publication:
Article
Pages:
35-41
Authors:
Yassin, F. A
DOI:
10.1007/s10593-009-0222-x
Journal:
CHEMISTRY OF HETEROCYCLIC COMPOUNDS SPRINGER
Volume:
45
Research Area:
Chemistry
ISSN
ISI:000266138900003
Keywords :
isoxazolopyridine, pyrazolopyridine, pyridine-3-carbonitrile, pyridoquinazoline, antibacterial activity
Abstract:
The reaction of 2-chloro-4,6-dimethylpyridine-3-carbonitrile with hydrazine hydrate, hydroxylamine, and anthranilic acid afforded the corresponding pyrazolo, isoxazolo, and pyridoquinazoline derivatives. Alkylation of 2-mercapto-4,6-dimethylpyridine-3-carbonitrile with ethyl chloroacetate or phenacyl bromide followed by cyclization in NaOH gave thienopyridine derivatives. Diazotization of ethyl 3-amino-4,6-dimethylthiD mu no{[}2,3-b]pyridine-2-carboxylate followed by the reaction with thiourea, guanidine carbonate, and hydroxylamine hydrochloride gave the corresponding thienopyridine derivatives. The biological activity of some new compounds has been discussed.
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