The effect of transplacental exposure to some tumorogenic agents

The oral LD50 of Gclecron in Agoza strain ruts wast:lund to be 12.50 mg/kg. .Animals survived nfter det-orel LD50J were left for 11 months thenfindings were the presence of squrumous;Jilloma in the non-glandulo.r gastric muoo an of thestomach Intestine showed partio.1ly hyper-p.Las La of liningepithelium, ’haemo.rrhngic areas were seen in the muooaa ,The effect of Galoeron on nonpregnant femele ratslIB investigated by intro.gastric intubation of threecroups by LD50, % LD50 and -- L~ lbses.10 Symptoms included dyspnea, paralysis of hind l~nbs,c:lnvulsions end dea.th. The post-Mortem findings werefoci on the surface of the live~J congesthinning of the stomach - wall.The histopathologicul excminction showed toxog- enic effects on different organs and the lesions were dose related