Responses of rats exposed to dieldrin containing diet for six months

Blood samples were taken to study effect of chronictoxicity of dieldrin on blood picture, ano levels ofsome biochemical constituents in the serum. Tissue samplesVler9 taken f rom liver, kidneys, he art, 1 unr s , inte stinesspleen, testicles, ovaries, uterus, and brain, to carryout the h Ls t opa t ho Lo gf.c a I examination as well as tumourincid ence.The signs and symptoms of chronic toxicity of dieldrinin rats were noted. The insecticide exerts its action on~.N.S. This wes manifested by irritability tremors foll-owed by toxic and clonic convulsion. At the terminal stageof experiment, 108s of body weight ,- exhaustion, weaknessend emaciation. Intermittent enile~tic con~lsion were ob-serverl end r~ts sho~ed rou~h coats rnd arched baCK.Deterrninetipn of heemr:tological values \’BS cAT:-iedout ev~ry two weeks in order to investigate the chroniceffect of dieldrin on blood picture. ~aemoglobin r- nowerlin the female and male treated rets a marked decreasebeing (15.05 +0.66)% (control 17.7± 0.5)% and 13.2±O.A7)(control 15.5 ± 0.(,2) r re~Dectively. The erythrocytic countin the female treated rats showed in some cases a highlysignificant decrease being (4.04 ± 0.27) (control (.20 ±