Effect of some drugs on enzymatic activity and some serum electrolytes of guinea pigs injected with tetanus toxin

In the present work the effect of some drugs on enzymatic activity and se~m electrolytes of guinea pigspreviously injected with tetanus toxin were studied.These drugs were.tetanus antitoxin t pro~aine p~illin, .G, combelen, thiocolchicoside, and pralidoximechloride.The minimum lethal dose of tetanus to:dn as well as the proteotive dose of tetanus antitoxin guinea pigsWGre determined and were found to be 1 ml. from dilution/ guinea pig and 8000 I.U. tetanus antitoxin/ kg. 40000’ b. wt. respectively.Eleven groups of five guinea pigs weighing from 330 _ 380 gm •• VlGre used. The first group was kept as un- ..•. inJected untreated control. from the 2nd to 11th group were ingected with 1 MLD of tetalluS toxin sub cut a.11eously.The 2nd group was kept as injected withtoxin untreated.