| Abstract: |
The present work was carried out to. study the haematological, biochemical and histopathological changes in rats experimentally infested withi Trichinella spiralis. One hundred and twenty rats were divided into2 equal groups (groups 1 and 2). Group 1 was subdivided into 6 equalsubgroups. Subgroups 1,2 and 3 were orally given 300 larvae of Trichinella spiralis, subgroups 4, 5 and 6 were control. Group 2 was subdivided into 6 equal subgroups. Subgroups 1,2 and 3 were infested with 300 larvae of Trichinella spiralis. Subrgroups. 1thiabendazole) and sacrificed 3 days after the 3 rd dose. Subgroups 1 , 2and 1 beside their control, in both groups, were sacrificed 4 (intestinalphase), 15 (migratory phase), and 60 (cystic phase) days postinfectionrespectively. The haematological findings showed severe leucocytosis,eosinophilia and lymphocytosis specially in gp.l-. Subgroups 2,3(Migratory and ’cystic phases). It was mild in gp.l subgroup 1 (intestinalphase), gp.l subgroup 4, 5. Highly severe eosinophilia in gp.2 subgroups6 could be due to the toxic effect and tissue reaction against the thiabend-;azole The :clini~obiochemica,lanalysis:showed a picture of cholestatichepatocellular Jaundice in all animals. This picture was manifested byhighly increased leveles of y .GTp, S. GOT, S. GPT and AP in addition tototal, di rect and indirect bilirubin specially in gp.l subgroup 2 and veryhighly increased levels in gp.l subgroup 3 and mild increased levels ingp. 1 Subgroup 1. The hepatocellular damage was manifested by
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