The persent work was planned to study Bome biochemical manges in the blood of oows and bQffaloes whioh aocompaniedthe gestation period and early puarperium stage~’”The anim.’11s ware aeleotecl from El~KhQttarQ farms, SharkiaGovernment. Clfter being examined by reotal palpation. t o. ooni’i:tmpregnm]oJ’ • ’” During the period of experiment the anil1lDls, were kept~der veterinary supervision to avoid any comp~oationB whioh!In.\” Q ocompony pnegnanoy,The blood serum samples wore colleoted ~nthly to determinethQ f’!,llow1ng parQme~ers&Caloium, ;.; InorgauJ.o phospho rus,Magno si um, ..; lro1l. Sodium.potoBsium ; Total proteins end protein fractions