Disposition kinetic of josamycin and Trimethoprim in fowls

In the present work, the pharmacokinetic profiles ofjosamycin, trimethoprim and their combination wasstudiedfollowing orally and intramuscular administration in 71normal fowls.Bioavailability of josamycin were calcula-ted in normal fowls after oral and intramuscular adminis-tration. The concentrations of josamycin and trimethoprimin serum and tissues were assayed microbiologically andchemically respectively.Josamycin:Following a single oral administration of josamycin(18 mg/kg b.wt) in normal fowls, a maximum serum concentr-ation was recorded at 2 hours, with half-life of absorption[to.5(ab)] valued with 0.77 h.[to.5(~)] was 2.85 h.The elimination half-lifeIFollowing a single intravenous injection of (18 mg/kg b.wt )in normal fowls previously given the same dose of josamycin orally,the drug obayed a two-compartments open model with half-lifeof distribution [to.5(a::)] of 0.27 h., [VI]’ [V2] and [Vdss]were equal to 163.17, 166.50 and 329.67 ml/kg, respectively.The ~ean systemic bioavailability following oral dose was33.88%.During repeated oral administrations of 18 mg/kg b.wtonce daily for five consecutive days in normal fowls, the