Adenine and benzimidazole-based mimics of REP-3123 as antibacterial agents against Clostridium difficile and Bacillus anthracis: Design, synthesis and biological evaluation

Faculty Pharmacy Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Kamel Abdelrehem Metwaly Bayomy
Journal: Bulletin of Faculty of Pharmacy Cairo University Elsevier Volume:
Keywords : Adenine , benzimidazole-based mimics , REP-3123 , antibacterial agents    
Abstract:
As part of our ongoing research efforts to develop new antibacterial agents acting on novel molecular targets, a series of twenty-two adenine and benzimidazole-based mimics of the lead compound REP-3123 was designed to target methionyl-tRNA
    
     
 
       

Author Related Publications

  • Kamel Abdelrehem Metwaly Bayomy, "Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study", ELSEVIER, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone‑based rhodanines", Springer Open, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", taylor and francis online, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone-based rhodanines", Springer, 2017 More

Department Related Publications

  • Abdallah Ahmed Abdallah Elshanawany, "Synthesis of 3- substituted (6-bromo-2-imidazo{4,5-b}pyridinyl)propionic acid as antiinflammatory agents. ", لايوجد, 1900 More
  • Abdallah Ahmed Abdallah Elshanawany, "Determination of dexchlorpheniramine maleate and dipyrone in bulk powder and in pharmaceutical preparations using chloranilic acid as acceptor. ", لايوجد, 1900 More
  • Kamel Abdelrehem Metwaly Bayomy, "Structure-activity relationship investigation of methoxy substitution on anticancer pyrimido[4,5-c]quinolin-1(2H)-ones", Springer, 2013 More
  • Mansour Alsayed Mansour Abokol, "SYNTHESIS OF SOME PYRIMIDO(4,,5,: 4,5) PYRIMIDO(1,6- A) INDOLE OF POTENTIAL ANTIINFLAMMATORY ANTIPYRETIC ACTIVITIES", Zag. J. Pharm. Sci.,Vol 4,No. 1, pp 36 - 42(, 1993 More
  • Mansour Alsayed Mansour Abokol, "REDUCTION OF 2, 3-DICHLOROMALEIC ANHYDRIDE III; ACYLATIVE REDUCTIVE ELIMINATION", Boll. Chim. Farmaceutico – Anno 136 –pp.685-690 n11 Dicembre (, 1997 More
Tweet