Synthesis and biological activity of 2,5-diaryl-3-methyl-pyrimidino[4,5-c]quinolin-1(2H)-one derivatives

Faculty Pharmacy Year: 2007
Type of Publication: ZU Hosted Pages:
Authors:
Kamel Abdelrehem Metwaly Bayomy
Journal: Bioorganic and Medicinal Chemsitry Elsevier Volume:
Keywords : Synthesis , biological activity , 2,5-diaryl-3-methyl-pyrimidino[4,5-c]quinolin-1(2H)-one derivatives    
Abstract:
A series of 2,5-diaryl-3-methylpyrimido[4,5-c]quinolin-1(2H)-ones (7-30), variously substituted at the 2- and 5-phenyl moieties, were synthesized and evaluated for their in vitro cytotoxic activity against a PC3 cancer cell line. Cytotoxici
    
     
 
       

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