Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: synthesis and in vitro cytotoxic activity

Faculty Pharmacy Year: 2007
Type of Publication: ZU Hosted Pages:
Authors:
Kamel Abdelrehem Metwaly Bayomy
Journal: European Journal of Medicinal Chemistry Elsevier Volume:
Keywords : Pyrimido[4,5-c]quinolin-1(2H)-ones , , novel class , antimitotic agents: synthesis    
Abstract:
Several 2-amino-pyrimido[4,5-c]quinolin-1(2H)-ones variously substituted at positions 3, 5, and 9 were prepared from their corresponding lactones. The target compounds were investigated for in vitro cytotoxic activity against a panel of hum
    
     
 
       

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