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Spectroscopic, thermal and biological studies of coordination compounds of sulfasalazine drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) transition metal complexes
Faculty
Science
Year:
2009
Type of Publication:
Article
Pages:
205-214
Authors:
El-Megharbel, S. M, Refat, M. S, El-Wahed, M. G. Abd
Journal:
BULLETIN OF MATERIALS SCIENCE INDIAN ACAD SCIENCES
Volume:
32
Research Area:
Materials Science
ISSN
ISI:000268198600015
Keywords :
Infrared spectra, electronic spectra, thermal analysis, sulfasalazine, antimicrobial activity
Abstract:
The complexations of sulfasalazine (H(3)Suz) with sonic of transition metals have been investigated. Three types of complexes, {[}Mn(HSuz)(-2)(H(2)O)(4)]center dot 2H(2)O, {[}M(HSuz)(-2)(H(2)O)(2)]center dot xH(2)O (M = Hg(II), ZrO(II) and VO(II), x = 4, 8 and 6, respectively) and {[}M(HSuz)(-2)(Cl)(H(2)O)(3)]center dot xH(2)O (M = Cr(III) and Y(III), x = 5 and 6, respectively) were obtained and characterized by physicochernical. and spectroscopic methods. The IR spectra of the complexes suggest that the sulfasalazine behaves as a monoanionic bidentate ligand. The thermal decomposition of the complexes as well as thermodynamic parameters (Delta E{*}, Delta H{*}, Delta S{*} and Delta G{*}) were estimated using Coats-Redfern and Horowitz-Metzger equations. In vitro antimicrobial activities of the H(3)Suz and the complexes were tested.
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