Ketanserin and spiperone as templates for novel serotonin 5-HT2A antagonists

Faculty Pharmacy Year: 2002
Type of Publication: ZU Hosted Pages:
Authors:
Kamel Abdelrehem Metwaly Bayomy
Journal: Current Topics in Medicinal Chemistry BenthamSciences Volume:
Keywords : Ketanserin , spiperone , templates , novel serotonin 5-HT2A    
Abstract:
The structures of ketanserin (1) and spiperone (2) were examined in detail to determine the role of various substituent groups on 5-HT(2A) receptor affinity and selectivity. It was found that the presence of the quinazoline ring of ketanser
    
     
 
       

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