Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding

Faculty Pharmacy Year: 1998
Type of Publication: ZU Hosted Pages:
Authors:
Kamel Abdelrehem Metwaly Bayomy
Journal: Journal of Medicinal Chemistry ACS Volume:
Keywords : Spiperone: influence , spiro ring substituents , 5-HT2A    
Abstract:
Spiperone (1) is a widely used pharmacological tool that acts as a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist. Although spiperone also binds at 5-HT2C receptors, it is one of the very few agents that display some
   
     
 
       

Author Related Publications

  • Kamel Abdelrehem Metwaly Bayomy, "Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study", ELSEVIER, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone‑based rhodanines", Springer Open, 2017 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", taylor and francis online, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 More
  • Kamel Abdelrehem Metwaly Bayomy, "Synthesis and anticancer activity of novel quinazolinone-based rhodanines", Springer, 2017 More

Department Related Publications

  • Sobhi Mohamed Mahmoud Ibrahym, "Determination of some Pharmaceutical Carbonyl Compounds", لايوجد, 1900 More
  • Mohammed Alhuseiny Abdelhamid Elsadek , "Continuation For Chemical Methods For Analysis of Some Antibiotics", لايوجد, 1900 More
  • Abdallah Ahmed Abdallah Elshanawany, "Stability indicating spectrophotometric method for determination of Moexipril HCl ", لايوجد, 1900 More
  • Abdallah Ahmed Abdallah Elshanawany, "Synthesis of new 1,2,4-Triazoloquinazoline derivatives as CNS modulators ", لايوجد, 1900 More
  • Abdallah Ahmed Abdallah Elshanawany, "HPLC Determination of Amoxicillin,Metronidazole and pot. clavulanate in combination mixture in presence of their degradation products ", لايوجد, 1900 More
Tweet