Synthesis and pharmacological activity of some synthesized polyazacyclopenta{[}a]naphthalenes and pyrazolo{[}3,4-b]pyridines using 2-amino-6-methyl-4-phenylnicotinonitrile as synthon

A series of pyridines, pyrimidines, and their derivatives were synthesized using 2-amino-6-methyl-4-phenylnicotinonitrile as starting material. Thirteen new heterocyclics containing a pyridine ring were thus prepared. Pharmacological screening showed that many of these compounds have good anti-inflammatory and analgesic activity comparable with those of diclofenac potassium and valdecoxib as reference drugs. Assignment of the structures of the new compounds was based on chemical and spectroscopic evidence. Synthesis, spectroscopic data, and pharmacological properties of the compounds are reported in detail.