6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase

Faculty Science Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Abdullah Elsayed Abdullah Hassan
Journal: European Journal of Medicinal Chemistry Elsevier Masson SAS. Volume:
Keywords : 6-Methylpurine derived sugar modified nucleosides: Synthesis    
Abstract:
Impressive antitumor activity has been observed with fludarabine phosphate against tumors that express Escherichia coli purine nucleoside phosphorylase (PNP) due to the liberation of 2-fluoroadenine in the tumor tissue. 6-Methylpurine (Me
    
     
 
       

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  • Abdullah Elsayed Abdullah Hassan, "Lithium Hexamethyldisilazane Transformation of Transiently Protected 4‑Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation", American Chemical Society, USA, 2016 More
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