6-Methylpurine Derived Sugar Modified Nucleosides: Synthesis and Evaluation of their Substrate Activity with Purine Nucleoside Phosphorylases

Faculty Science Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Abdullah Elsayed Abdullah Hassan
Journal: Bioorganic Chemistry Elsevier Volume:
Keywords : 6-Methylpurine Derived Sugar Modified Nucleosides: Synthesis    
Abstract:
6-Methylpurine (MeP) is cytotoxic adenine analog that does not exhibit selectivity when administered systemically, and could be very useful in a gene therapy approach to cancer treatment involving Escherichia coli PNP. The prototype MeP r
    
     
 
       

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  • Abdullah Elsayed Abdullah Hassan, "6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase", Elsevier Masson SAS., 2016 More
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