Electrospray mass spectrometric studies of a potential antitumor drug and its analogous platinum(II) and platinum(IV) complexes with the ethylenediamine-N,N `-di-3-propanoato ligand and its dibutyl ester

The electrospray mass spectrometric (ESI-MS) behavior of the complexes trans-dichloro(ethylenediamine-N, N'-di-3-propionato) platinum(IV), trans-dibromo(ethylenediamine-N, N'-di-3-propionato) platinum( IV), dichloro (ethylenediamine-N,N'-di-3-propionic acid) platinum(II), tetrachloro(O,O'-di-n-butyl-ethylenediamine-N,N'-di-3-propanoate) platinum(IV), chlorotribromo(O,O'-di-n-butylethylenediamine-N,N'-di-3-propanoate) platinum(IV), and dichloro(O,O'-di-n-butyl-ethylenediamine-N,N'-di-3-propanoate) platinum( II), with the formulae trans-{[}PtCl(2) (eddp)] (1), trans-{[}PtBr(2)(eddp)] (2), {[}PtCl(2)(H(2)eddp)] (3), {[}PtCl(4)(Bu(2)eddp)] (4), {[}PtBr(3)Cl(Bu(2)eddp)] (5), and {[}PtCl(2)(Bu(2)eddp)]center dot H(2)O (6), is reported. The deprotonated molecular ions or halide adducts are usually observed. ESI-MS data demonstrate the usefulness of the method for efficient characterization of metal complexes in solution.