Lithium Hexamethyldisilazane Transformation of Transiently Protected 4‑Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation

Faculty Science Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Abdullah Elsayed Abdullah Hassan
Journal: Organic Letters American Chemical Society, USA Volume:
Keywords : Lithium Hexamethyldisilazane Transformation , Transiently Protected 4‑Aza/Benzimidazole    
Abstract:
Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58−88% yields. This strategy offers a much better choice
   
     
 
       

Author Related Publications

  • Abdullah Elsayed Abdullah Hassan, "A novel polystyrene/epoxy ultra‐fine hybrid fabric by electrospinning", Wiley, 2018 More
  • Abdullah Elsayed Abdullah Hassan, "6-Methylpurine Derived Sugar Modified Nucleosides: Synthesis and Evaluation of their Substrate Activity with Purine Nucleoside Phosphorylases", Elsevier, 2016 More
  • Abdullah Elsayed Abdullah Hassan, "6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase", Elsevier Masson SAS., 2016 More
  • Abdullah Elsayed Abdullah Hassan, "Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA", Taylor & Francis, 2018 More
  • Abdullah Elsayed Abdullah Hassan, "Cyano Modification on Uridine Decreases Base-Pairing Stability and Specificity through Neighboring Disruption in RNA Duplex", Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2018 More

Department Related Publications

  • Atef Mohamed AbdelHamid Ali Hassn, "heterocyclization of thiouracil derivative: synthesis of thiazolopyrimidines, tetrazolopyrimidines and triazolopyrimidines of potential biological activity", elsevier, 2015 More
  • Haitham Mahmoud Amin Hassan Ashry, ". Electrochemical response of natural and induced passivation of high strength duplex stainless steels in alkaline media", Journal of Solid State Electrochemistry, 2012 More
  • Mohamed Alaa Addeen Fathy Mohamed, "Novel Sensors for Batch and Flow Injection Analysis of Histamine Based on Crown Ethers", USA, 2012 More
  • Hammad Fattouh AbdelGaffar Mohamed Barakat, "Complexes of the plant hormone gibberellic acid with the Pt(II), Au(III), Ru(III), V(III), and Se(IV) ions: preparation, characterization, and in vitro evaluation of biological activity", ElSevier, 2019 More
  • Maher Abdul Rahman Shams al-Din Safty, "INTERNATIONAL JOURNAL OF INNOVATIVE RESEARCH & DEVELOPMENT", IMPACT FACTOR 1.8, 2016 More
Tweet