The role of serum gonadotrophin binding protein in regulating the estrous cycle of rats

In the present study it was decided to investigate the possible role played by non steroidal serum albu- mins in r-e gu La-t i ng the synthesis, secretions and tran-sport of gonedotropins during the estrous cycle of rats.For this purpose the following was performed:1- Determination of LH and FSH contents of the pituitary and serum of rats during seven stages of 5-day estrouscyc le.2- Determination of protein binding capacity by 2 methods;the first is direct neutralization in which serum sample being cleared from non-specific agglutinins and tested against varying dilutions of the specific homologus hor- mone, the second by indirectdifference between the first and the second reading was calculated.3- the effect of non-steroidal albumin fractions of large and small molecular sizes (ob~ained from female rats