Clinco-pathological evaluation of fascionide with comparison to other fasciolicide drugs

The aim of the pr-es errt study is to evaluate a new synthetic drug ”Easc i.on Lde” produced by El-Nasr Co. EgyptThe study included also a ’clinical and laboratory comparison w i.t h other anthelmintics drugs produced bydifferent Fil.~ms; namely Dirian 15% suspension (Bay er j ;Bilevon-R tablets (Bayer) and Coriban 20% susponsion (Wellcome) • The study included the following experiments:I. Toxicity Experiments:Different laboratory animals were used to invest-i.- gate the acute oral toxicity; LD50 and the highest therapeutic dose; consequently tro reach the suitable therapeutic dose for.field application in Egyptian farm animals and under the environment al conditions. Numbers of laboratory animals in these experimentsconstituted 100 mice; 65 r-at s ; 32 guinea-pigs; 40· rabbitsand 20 she ep • The drug was given orally at different doses; theLD50 050 mg/mouse weighing 20 gm; 190’ mg/kg body weight