Some Pharmacological Studies On Ketamine HCl And Its Interaction With Xylazine

the pUrpose of this studY pharmacodynamic proP1lri ties ;of k ~ 1$ ’so’me possi ble inte~aot1ons due to, , WIG with l3’lazine as a prerilaestheti ,to” invest1gat,.OIle~amin~ HGl . and . probe ”’,:its s1mtaneo.usagent. , !aits on .thj ~mo.oth m~sle S.’I Experiments p,erformed on the intestinal smootll .amusoles revealed a dose-dependant inhibitory efte.ct o~Ketamine HOl on the’ intestinal moti11 ty of guinef- p,!g,iium.lhe ’site of action was proved direct onthe intestinal’musculature ..•l3’la~ine.i1lhibited the motility of the g~l2ea pig.ileum and’ potent,ted the inhibitory effect of Xetam1neon the isolated intestime • . Ketamine H~l, in differnt’doses~’i~ibit~d th ’; uterine motility of rats at different ~tages of sex oycle, the site of action was’ proved to’ be ’,’a cU:rect’,oneon the uterine. muscu’l.at ure , Xylazine inhibited ,the’:uterine mtiiity of tb.e ·nonjoe~trusut·erua. pot.nti-ated theinhibi tory effeot ot ’Ketam1ne :Hcl-:on ’tlieuterinemusculature.