The effect of the insecticide sumicidin on theuterine muscles of rats in different stages of pregnancy

In this experimental work, the effects of sumicidin on the motility of the rot uteruo in vitro as well as in vivo Vlere investit;ated. Effects on the isolated smooth museles:-~~e effect of the drug was investigated in non prQ- nnnt and pregnant rat uteri in different stages of pre-gnancy (early, mid Gnd late pregnancy).t\.t 10-;: concentrations, a prominent inhibition WaS cieve by the crug on non pregnant, early, mid and latepregn~t uteri, By increasing the doses, full relaxation \’iUS recorded.L~e inhibitory effect of the drug might be due to an atropine-Like activity a8 acetylcholine failed to produceita stimulatory effect in the presence of sunicidin on non pregnant uteri, but induced a very sli~ht stimulation onearly pregnant rat uteri. On mid and late pregnant uteri , acetyl choline’s effect became more pronounced, but still considerablY less than its effect alone. On these stages the high level of oestro~en might play a role increasing the response of etyl choestrase activity.