Synthesis and Pharmacological Studies for New Benzotriazole and Dibenzodiazepine Derivatives as Antipsychotic Agents

New benzotriazoles (5-8) or dibenzodiazepine derivatives (11-18) were synthesized starting from 3-{[}(2-amino-4,5-disubstitutedphenyl)amino]-5,5-disubstitutedcyclohex-2 -enones(1-4)through internal coupling of their diazonium salts or internal Mannich reaction in the presence of aromatic aldehydes. Pharmacological evaluation of benzotriazole and dibenzodiazepine derivatives for their clozapine-like properties revealed that dibenzodiazepine I I bearing 4-bromophenyl group exhibited the same antipsychotic activity as the reference drug clozapine while the activity of benzotriazole 7 was 25\% lesser than that of clozapine. Moreover, compounds 7 and I I did not show significant CNS depressant activity as well as no or slight neurotoxicity on contrast to clozapine when tested in mice using forced swim, rotarod and horizontal screen tests.