Immunopathological Studies Of Expeerimental Mammary Carcinogenesis Induced By Dmba In Rats Effect Of Bcg Vaccine

To study the effect of BCG vaccine on the modulation of the immune mechanisms involved in mammary tumor growthas well as its effect on the morphology of the expected growth and the use of histochemical indices as different-ial parameters between preneoplastic, benign and malignant changes in mammary tumorigenesis, the following experimentwas designed:1- Caicin£gen_gro~~ included 25 rats. Every rat received a single 1 ml dose of 20 mg DMBA in corn oil.11- BCG-treated group : included 25 rats. Every rat wasvaccinated with 0.3 mg BCG in 0.1 ml dose intra- dermally 15 days prior to carcinogen administration.111- Control£rouEs~ included5 rats receiving corn oil alone.5 rats receiving BCG alone.5 untreated normal rats.Administration of the carcinogen into the female adult Egyptian rats induced the following sequential mammarylesions:1-Mammary alterations with incidence of 27.3% through a period of 3 - 14 days.2- Preneoplastic mammary lesions in the form of: a- HANs with incidence of 9.09% through a period of 28 - 342