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Protective effect of Pleurotus cornucopiae mushroom extract on carbon tetrachloride-induced hepatotoxicity
Faculty
Veterinary Medicine
Year:
2009
Type of Publication:
Article
Pages:
109-118
Authors:
Hashimoto, Yoshiharu, Ikenaka, Yoshinori, Ishizuka, Mayumi, Muzandu, Kaampwe, Fujita, Shoichi, Ibrahim, Zein Shaban, El Bohi, Khlood M, Kazusaka, Akio
Journal:
JAPANESE JOURNAL OF VETERINARY RESEARCH HOKKAIDO UNIV
Volume:
57
Research Area:
Veterinary Sciences
ISSN
ISI:000270472900003
Keywords :
CCl(4), CYP2E1, cytochrome P450, mushroom, Pleurotus cornucopiae
Abstract:
Pleurotus cornucopiae (PC) mushrooms are found in the field and commonly known in Japan as Tamogidake mushrooms. The present study investigated the protective effects of an aqueous extract of PC on carbon tetrachloride (CCl(4))-induced hepatotoxicity and the possible mechanism involved in this protection including cytochrome P450 (CYP) 2E1. Wistar rats were pretreated with aqueous extracts of PC (0, 100, 200, and 400 mg/kg) orally for 8 days prior to the intraperitoneal. administration of a single dose of CCl(4) (0.5 ml/kg) or corn oil. Pretreatment with PC mushroom extract significantly prevented the increased serum enzyme activities of alanine and aspartate aminotransferases in a dose-dependent manner, and suppressed the expression of CYP2E1. PC mushroom extract also protected hepatocytes from the damage effects of CCl(4) as remarked by histological and electromicroscopical findings. It was concluded that repeated daily doses of aqueous extracts of PC mushroom reduced the toxic effects exerted by CCl(4) on the liver.
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