Effect of some antiprotozoal drugs on reproduction in laboratory animals

In this investigation the teratogenic effects of nitrofurantoin and su.lphametho~diazine, beside theireffects on male rat fertility, were atrudd.ed 0 A_~Teratogenic effects:Five groups each of 20 pregnant fema’le ra+.:;s were used for revea1ing,iihe dysmorphogenic effec’l;s OL these dI’UgS after their Eidministration to pregnant mothers at 6 15!i1l dayof gestation1- Nit:rotur8.l~toin in doses of 50 and 100 mg/kg b~wt!casused 6~62% ,16!47% resorption, 5~}O%, 28~23% mortality, 3~OO ± O~2.0 and 3~39 ±. O~18 (significant p Ob05) average weight of foetuses/ g~ 26~44 ± 0~EBj24~77 ± 1~03 (highlysignificant p O~Ol) average length of foetllS6s /m.-rn and100/86.7, 100/79~7 sex/ratio, relatively with :L~82. %re sorption , 0.61% death, 3.91 + 0.17, foetal weight/g., 29~90 ± O~59, foetal lengtb/mm and 100/91.!7 sex ratio inthe control group respectively