Some Toxicological studies on rodenticide racumin

Racumin ’Ba,Yer’ 3( x - tetralyl) -4~ hydroxy coum-is on~ of tbe anticoagulant group of rodeLticidesimC:j.’Ll.ding warfarip, coum~chlor, ’fUIJlarin El ne. p i va L, Itwasdiseovered in 1956/1957 as a. pew actin iLgrea.ientbased on coumarin.Jur pet anima:Ls are liable to be eith”-’I”pnisoneJ;secondrily poisone~ by such compound dur~ng theirfor eradieation of rodents.There is no much in literature regarding this spe-compound, although several work has becn done reg~arding other members of the group.To study the effect of this compound on d0gs, itwas first essential to determine its t oxf.s doses tothem, As ’a r’e su l t of our experiments for repeated adm-instration which is in nature the real COUse for toxi-city, licking the bait for rats, these doses were deter-mine d, The LD50 was found to be Lmg ./Kg. B. Wt. Accordingto the method of Be hr-ens and Karber, (1953) used for itsdetermination l/7 of this dose (0.15 rng./Kg. B.Wt.) wasgiven 0rally to dogs for seVen successive days. Thisdose was used through-out all our experiment.Symptoms observed on dogs thus treated, were:dullness, anorexia, thirst, respiratory distress, bloody