Effect Of Some Cns Depressants On Reproduction In Laboratory Animals

In this Lnve at Lgac i on tera-co.genic effects of diethyl ether, pentobarbitone sodium and xylazine hydrochloride beside -cheir effect on male fertility in rats werestudied. A- TerEd; ogenic Effect s:Seven groups each of 20 pregnant femal- rats were used for revealing the dysmorphogenic e f’f’e cb of these drugs after their administration to pregnant mothers at 6 th - 15lh day of gestation. 1- Inhalation of diethyl ether in concentrations of 0.2% and resor~tion, 3.25, 7.10% mortality, 3.86 ± 0.11, 3.67 ± 0.17 weight/g, 27.25 +0.73, 26.63 ± 0.95 length/nun. and 100/166.1 , 100/127.1 sex ratiocorresponding to 1.82 resorption, 0.61% mor-t a’l i t y , 3.91 ± 0.17, foetal weight/g, 29.90 ± 0.59 foetal length/mm and 100/91.7 sex ratio in thecontrol respectively. Moreover, this drug c auae i some visceral abnormalities in the foetuses as6 • .38 and 16.28% microcephaly ~ abnormal d eve Lcpme.nt of the brain, 0.0 and 2.32% 01eft palate, 4.25and 18.60% cardiomegaly and 0.0 and 9.30% hydronephrosis in the tested doses respectively.