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A single immunization with a recombinant canine adenovirus type 2 expressing the seoul virus Gn glycoprotein confers protective immunity against seoul virus in mice
Faculty
Veterinary Medicine
Year:
2009
Type of Publication:
Article
Pages:
5247-5251
Authors:
Yuan, Zi-Guo, Li, Xiu-Ming, Mahmmod, Yasser Saad, Wang, Xiao-Hu, Xu, Hui-Juan, Zhang, Xiu-Xiang
DOI:
10.1016/j.vaccine.2009.06.062
Journal:
VACCINE ELSEVIER SCI LTD
Volume:
27
Research Area:
Immunology; Research \& Experimental Medicine
ISSN
ISI:000269071900015
Keywords :
Seoul virus, Canine adenovirus type 2, Gn, Mice, Immunity
Abstract:
Seoul virus (SEOV), a member of hantavirus genus, is one of the causative agents of hemorrhagic fever with renal syndrome (HFRS) and afflicts tens of thousands of people annually. In this paper, we evaluate the immune response induced by a replication-competent recombinant canine adenovirus type 2 expressing the Gn protein of SEOV (rCAV-2-Gn) in BALB/c mice. Sera from immunized mice contained neutralizing antibodies that could specifically recognize SEOV and neutralize its infectivity in vitro. Moreover, the recombinant virus induced complete protection against a lethal challenge with the highly virulent SEOV strain CC-2. Protective level neutralizing antibodies were maintained for at least 20 weeks. The efficacy of the recombinant was similar to that induced by a currently available inactivated HFRS vaccine. This recombinant virus is therefore a potential alternative to the inactivated vaccine. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
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