Pathological and cytopathological studies on the effects of radiation on the cerebellum

Expos ur e of 355 adult mat ui.e , male and female mice to X-irradiation was carried 9.S follows:~.h.e.f i.rst ex-.£e~:i.mentt whole body exposure of 4 grOUJ?8 ofaic e in the fol.~ of single dose of 50, 200, 400 or 600 rads for each group_ !llLse.£.ond_~eJ92s:r:.:i,..iIlent, an o t her 4 Groll.C)S of mice were expo-sed to single localized be ad ir:r:’aCi ~L.at;ion of the aaae d OBe smentioned above.~hE?. t.hi:lC”,§,~P_~.r)..li1~n~ s repeated whole body expo sure , wasapplied on 3 groups of mice exposed to 10, 20 and 50 rads weekly and the exposure was repeated for four successive weeks, where each group .received a to•tal dose of 4-0, 80 01.’ 200 rad l.’€spectively.The exposures were applied by using a KilovoltaE;€machine (200 kv , 10 MA, 1 m cu , H~V~T~ and 50cm F.S~D.) ln nhe d oae r abe of 21 rad/min. .All b hs irI’adiated animals werG put under observation and .examined for behavioural changes, gross and microscopic al’~ e~a-iiion for 4 weeks post- irr’ad ia ti