Clinicopathological studies on some viral and bacterial vaccines in sheep

Investigation were carried out on 25 males sheep to evaluate theprogramme of vaccination of sheep in Sakha farm started at age 4 - 6months. Sheep were firstly vaccinated with first dose against foot andmouth disease (FMD) using inactivated FMD vaccine aftovaxins”France”. Then after two weeks, sheep were subjected to the first dosefrom covexin TM8 as combined clostridial vaccine ”England”, followedafter 7 weeks by the second dose. After two months from the lastvaccination, sheep were given the second dose from inactivated FMDvaccine. Two weeks later, the animals were vaccinated against sheeppox using live, attenuated tissue culture sheep pox vaccine obtainedfrom Veterinary Serum and Vaccine Research Institute, Abbasia, Egypt.The present study extent for 23 weeks in which the vaccinatedsheep were subjected to several laboratory examinations to evaluate theimmune responses of sheep to different vaccines and to evaluate theireffect on the health status of animals by using the haematologicalprofile, serum biochemical parameters and pathological studies.Sheep of Sakha farm were vaccinated with inactivated FMD in twodoses with intervals four months. The titre of immunized sheep weremeasured by serum neutralization test. from the 1 st week after firstvaccinal dose the neutralizing titre of antibodies showed aprogressiveincrease reaching its highest level 1.5± 0.1 log 10, at the 4th & 5th weekthen gradually declined until the 17th week to 0.5± 0.18 lOglO. Therevaccination of sheep stimulate the immune response of animals withapeak of neutralizing antibodies 1.5± 0.18 log I 0 at the 3rd week postvaccination, and continued at this high level till the 6th week post second