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Synthesis of new acridines and hydrazones derived from cyclic beta-diketone for cytotoxic and antiviral evaluation
Faculty
Pharmacy
Year:
2009
Type of Publication:
Article
Pages:
3680-3686
Authors:
El-Sabbagh, Osama I, Rady, Hanala M
DOI:
10.1016/j.ejmech.2009.04.001
Journal:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Volume:
44
Research Area:
Pharmacology \& Pharmacy
ISSN
ISI:000268744700040
Keywords :
Acridines, Hydrazones, Cytotoxic, Antiviral activity
Abstract:
Cyclic beta-diketone namely, dimedone was utilized to prepare different chemical entities whether cyclic such as acridines, thiadiazole and triazole or acyclic systems as hydrazide, hydrazones, thiosemicarbazide and semicarbazide. The structures of the novel compounds were deter-mined using elemental analyses and various spectroscopic methods. Most acyclic derivatives especially semicarbazide 19, hydrazide 9 and thiosemicarbazide 16 showed a higher in vitro cytotoxic activity against hepatoma cell line (HepG2) than the cyclized acridine derivatives. The antiviral activity of the new compounds against Hepatitis A Virus (HAV) using the plague infectivity reduction assay revealed that the acridine 4 and the hydrazone 12 were more active than the reference drug amantadine. (C) 2009 Elsevier Masson SAS. All rights reserved.
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