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Human C-reactive protein gene polymorphism and metabolic syndrome are associated with premature coronary artery disease
Faculty
Pharmacy
Year:
2013
Type of Publication:
Article
Pages:
216-221
Authors:
Abd El-Aziz, Tarek A, Mohamed, Rasha H
DOI:
10.1016/j.gene.2013.09.042
Journal:
GENE ELSEVIER SCIENCE BV
Volume:
532
Research Area:
Genetics \& Heredity
ISSN
ISI:000327174200009
Keywords :
hs-CRP, CRP gene, Polymorphism, Premature CAD, Metabolic syndrome
Abstract:
The aim of this study was to investigate the association between C-reactive protein (CRP) gene polymorphism and metabolic syndrome (MetS) with premature coronary artery disease (PCAD). 116 patients with PCAD (58 with MetS and 58 without MetS) and 119 controls were included in the study. CRP gene + 1059 G>C polymorphism was analyzed by polymerase chain reaction. Serum hs-CRP was measured using high-sensitivity enzyme-linked immunosorbent assay. Carriers of C allele of the CRP + 1059 G>C polymorphism had 337 fold increased risk to develop MetS in patients with PCAD. In addition CRP gene and hs-CRP levels were independent risk factors for PCAD and MetS. The present study provides new evidence that the presence of CRP +1059 G>C polymorphism and hs-CRP levels are independent determinants of PCAD and MetS in Egyptians. The results of our study suggest a synergistic effect of CRP C allele with classical risk factors such as hypertension, obesity, dyslipidemia and MetS. (C) 2013 Elsevier B.V. All rights reserved.
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