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Synthesis of new 2(1H)-quinoxalinone derivatives for antimicrobial and antiinflammatory evaluation
Faculty
Pharmacy
Year:
2009
Type of Publication:
Article
Pages:
782-797
Authors:
El-Sabbagh, Osama I, El-Sadek, Mohamed E, Lashine, Sayed M, Yassin, Shada H, El-Nabtity, Sameh M
DOI:
10.1007/s00044-009-9203-y
Journal:
MEDICINAL CHEMISTRY RESEARCH BIRKHAUSER BOSTON INC
Volume:
18
Research Area:
Pharmacology \& Pharmacy
ISSN
ISI:000272617700007
Keywords :
Antiinflammatory activity, Antimicrobial activity, 2(1H)-Quinoxalinones, Synthesis
Abstract:
New 2(1H)-quinoxalinones and their hexahydro derivatives were prepared for investigating their antimicrobial and antiinflammatory activities. The study showed that thiosemicarbazide 6a derived from the hexahydro-2(1H)-quinoxalinone series has nearly the same antibacterial activity as the reference drug ciprofloxacin. Moreover, the 2(1H)-quinoxalinones bearing N-phenyltriazole (9a) or 4-chlorophenyl-2,3-dihydrothiazole (13b) moieties were the most active ones after 4 h with use of the rat hind paw edema method, whereas their antiinflammatory and ulcerogenic activities were comparable with the selective COX-2 inhibitor celecoxib.
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