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Lipoprotein glycation in atherogenesis
Faculty
Not Specified
Year:
2009
Type of Publication:
Article
Pages:
781-790
Authors:
Younis, Nahla N, Soran, Handrean, Charlton-Menys, Valentine, Durrington, Paul N, Sharma, Reena
DOI:
10.2217/CLP.09.61
Journal:
CLINICAL LIPIDOLOGY FUTURE MEDICINE LTD
Volume:
4
Research Area:
Biochemistry \& Molecular Biology
ISSN
ISI:000272782500015
Keywords :
antiatherogenic lipoprotein, atherogenic lipoprotein, glycation, small dense LDL, statin
Abstract:
There has been increasing interest in investigating the role of glycation as an atherogenic modification of lipoproteins; especially after the failure of antioxidant therapy to suppress the incidence of atherogenic cardiovascular diseases in high-risk individuals. Glycation of lipoproteins impairs their function. In the case of LDL, it also leads to rapid scavenger-receptor uptake by monocyte/macrophages. Glycation also diminishes the antiatherogenic properties of HDL. The concentration of circulating glycated LDL, even in nondiabetics, is higher than that of oxidatively modified LDL. Glycated small dense,LDL is significantly higher in nondiabetic individuals as well as in Type 2 diabetic patients. Lowering the level of small dense LDL by using statins lowers glycated LDL in Type 2 diabetic patients. This may be one of the reasons for their-effect in decreasing cardiovascular risk in these patients. Treatments that prevent glycation of lipoproteins may prevent atherosclerosis and other diabetic complications.
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