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Synthesis, characterization and antimicrobial studies on cis-platinum(II) complexes of 5-nitrosouracil derivatives
Faculty
Specific Education
Year:
2010
Type of Publication:
Article
Pages:
146-151
Authors:
Gaballa, Akmal S
DOI:
10.1016/j.saa.2009.09.061
Journal:
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY PERGAMON-ELSEVIER SCIENCE LTD
Volume:
75
Research Area:
Spectroscopy
ISSN
ISI:000274773700023
Keywords :
Cis-Platinum(II), Pyrimidine derivatives, IR, UV-vis, (1)H NMR, TG, Antimicrobial
Abstract:
Two complexes were obtained during the reactions of 6-amino-1-methyl-5-nitrosouracil (AMNU) and 6-methylamino-1-benzyl-5-nitrosouracil (MABNU) with cis-diaquadiamineplatinum(II) nitrate complex, cis-{[}Pt(NH(3))(2)(H(2)O)(2)](NO(3))(2). The complexes were isolated in good yields as powdery precipitates. They were characterized through their elemental analysis, infrared, UV-vis, and (1)H NMR spectroscopies as well as thermal analyses. The obtained results indicated that, pyrimidine bases substitute easily aqua ligands and interact with Pt(II) ions as a monodentate ligand in the neutral and ionic form for the ligands AMNU and MABNU, respectively. The exocyclic oxygen atoms are the most probable binding site. Square planar structures, cis-form, wet e proposed in both cases. The free ligands, and their Pt(H) complexes were screened for their antimicrobial activities. (C) 2009 Elsevier B.V. All rights reserved.
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