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Assessment of Cell-Free DNA with Microvascular Complication of Type II Diabetes Mellitus, Using PCR and Elisa
Faculty
Medicine
Year:
2010
Type of Publication:
Article
Pages:
228-236
Authors:
El Tarhouny, Shereen A, Hadhoud, Khaled M, Ebrahem, Magdy M, Al Azizi, Nashwa M
DOI:
10.1080/15257771003708298
Journal:
NUCLEOSIDES NUCLEOTIDES \& NUCLEIC ACIDS TAYLOR \& FRANCIS INC
Volume:
29
Research Area:
Biochemistry \& Molecular Biology
ISSN
ISI:000277621100007
Keywords :
Nucleosomes, cell-free DNA, type 2 diabetes mellitus, microvascular complications
Abstract:
In order to assess the potential biochemical markers in the development, diagnosis, and prognosis of diabetic patient with microvascular complication represented with retinopathy, we analyzed the levels of cell-free DNA by two different techniques. The levels of cell-free GAPDH assayed by quantitative PCR were significantly higher in the plasma samples of diabetic patients with and without diabetic retinopathy than in those of the control group; thus, it is a better biomarker than nucleosomes assayed by ELISA in patients with type 2 diabetes for the early detection of development of microvasuclar complications as retinopathy.
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