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Kinetic spectrophotometric determination of hyoscine butylbromide in pure form and in pharmaceutical formulations
Faculty
Science
Year:
2010
Type of Publication:
Article
Pages:
33-38
Authors:
Gouda, Ayman A
DOI:
10.1016/j.arabjc.2009.12.006
Journal:
ARABIAN JOURNAL OF CHEMISTRY KING SAUD UNIV PRESS, KING SAUD UNIV
Volume:
3
Research Area:
Chemistry
ISSN
ISI:000290013700006
Keywords :
Kinetic determination, Hyoscine butylbromide, Potassium permanganate, Pharmaceutical analysis
Abstract:
A simple and sensitive kinetic method was described for the determination of hyoscine butylbromide in pharmaceutical preparations. The method is based upon a kinetic investigation of the oxidation reaction of the drug with alkaline potassium permanganate at room temperature for a fixed time of 15 min. The absorbance of the colored manganate ion was measured at 610 nm. The absorbance-concentration plot was rectilinear over the range of 1.0-10 mu g mL(-1) (r = 0.9999) and detection limit of 0.092 mu g mL(-1). The concentration of hyoscine butylbromide was calculated using the corresponding calibration equation for the fixed-time method. The determination of hyoscine butylbromide by the fixed-concentration and rate constant methods is also feasible with the calibration equations obtained but the fixed-time method has been found to be more applicable. The different experimental parameters affecting the development and stability of the colors were carefully studied and optimized. The proposed method was applied to the determination of hyoscine butylbromide in pharmaceutical formulations. The results obtained were in good agreement with those obtained using the official British Pharmacopeial method (2004). (C) 2009 King Saud University. All rights reserved.
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