Expression and Sequence of CYP1A1 in the Camel

Faculty Veterinary Medicine Year: 2010
Type of Publication: Article Pages: 221-224
Authors:
Journal: JOURNAL OF VETERINARY MEDICAL SCIENCE JAPAN SOC VET SCI Volume: 72
Research Area: Veterinary Sciences ISSN ISI:000275995500013
Keywords : camel, CYP1A, cytochrome P450, lung, tongue    
Abstract:
In this study, we determined a partial sequence of CYPIA1 in the camel and its phylogenetic position. The deduced amino acid sequence of camel CYPIA1 showed the highest identity 94\% with those of sheep and cattle CYPIA1. In a phylogenetic analysis, the camel CYPIA1 isoform was located beside sheep and cattle CYPIA1. When we studied the distribution of camel CYPIA1 mRNA in different tissues, we found that this isoform was expressed in all tissues except the hump. Interestingly, the lungs of all the camels and tongues of two of the three animals showed high expressions of CYPIA1 mRNA, and this may indicate exposure to ligands of aryl hydrocarbon receptor such as environmental pollutants or flavonoids.
   
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