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Probiotics Down-Regulate Genes in Salmonella enterica Serovar Typhimurium Pathogenicity Islands 1 and 2
Faculty
Veterinary Medicine
Year:
2010
Type of Publication:
Article
Pages:
452-460
Authors:
Bayoumi, Mohamed A, Griffiths, Mansel W
Journal:
JOURNAL OF FOOD PROTECTION INT ASSOC FOOD PROTECTION
Volume:
73
Research Area:
Biotechnology \& Applied Microbiology; Food Science \& Technology
ISSN
ISI:000275677900006
Keywords :
Probiotics Down-Regulate Genes , Salmonella enterica Serovar
Abstract:
Salmonella Typhimurium pathogenesis relies mainly on the expression of genes of two pathogenicity islands, Salmonella pathogenicity islands 1 and 2 (SPI1 and SPI2). Each island has its own pattern of expression and regulation. Success in suppression of the responsible key activator of each island would be an effective way of controlling Salmonella, especially with the emerging problem of antibiotic-resistant strains. Probiotics have been shown to inhibit several foodborne pathogens, and their mode of action may partly involve down-regulation of virulence genes. To investigate whether probiotics played a role in the regulation of the pathogenicity islands SPI1 and SPI2 in Salmonella, two reporter strains were constructed in which the general regulator of SPI1, hilA, and the response regulator of SPI2, ssrB, were fused with luxCDABE genes. These constructs were used to screen the effect of probiotics on the expression of each gene. Molecules secreted by Bifidobacterium bifidum were able to down-regulate both genes.
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