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Microbial l-methioninase: production, molecular characterization, and therapeutic applications
Faculty
Science
Year:
2010
Type of Publication:
Article
Pages:
445-467
Authors:
El-Sayed, Ashraf S
DOI:
10.1007/s00253-009-2303-2
Journal:
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY SPRINGER
Volume:
86
Research Area:
Biotechnology \& Applied Microbiology
ISSN
ISI:000274707600005
Keywords :
Antitumor enzymes, L-Methioninase, Properties, Therapeutic application
Abstract:
l-Methioninase is ubiquitous in all organisms except in mammals. It mainly catalyzes the, alpha, gamma-elimination of l-methionine to alpha-ketobutyrate, methanethiol, and ammonia. Unlike normal cells, methionine dependency was reported as a biochemical phenomenon among various types of cancer cells. Thus, l-methioninase is the universal protocol for triggering the majority of tumor cells. This review is an attempt to briefly describe the occurrence of the biochemical and molecular properties of l-methioninase by a comparative manner to the eukaryotic and prokaryotic source for the maximum exploitation in the therapeutic field. The combination of l-methioninase treatment, gene therapy, and chemotherapeutic drugs clearly explores the various therapeutic aspects of this enzyme. Finally, the perspectives for increasing the therapeutic efficacy of this enzyme were described.
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