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Cell-free placental mRNA in maternal plasma to predict placental invasion in patients with placenta accreta
Faculty
Medicine
Year:
2010
Type of Publication:
Article
Pages:
30-33
Authors:
El Behery, Manal M, El Alfy, Yehya, Rasha L, Etewa
DOI:
10.1016/j.ijgo.2009.11.013
Journal:
INTERNATIONAL JOURNAL OF GYNECOLOGY \& OBSTETRICS ELSEVIER IRELAND LTD
Volume:
109
Research Area:
Obstetrics \& Gynecology
ISSN
ISI:000276541400009
Keywords :
Cell-free placental messenger RNA, Color Doppler, Placenta accreta, Ultrasound
Abstract:
Objective: To evaluate whether measuring cell-free placental mRNA in maternal plasma improves the diagnostic accuracy of ultrasound and color Doppler in detecting placental invasion in patients at risk for placenta accreta. Methods: Thirty-five singleton pregnant women of more than 28 weeks of gestation and at risk for placenta accreta underwent ultrasound and color Doppler assessment. Cell-free placental mRNA in maternal plasma was measured using real-time reverse-transcription polymerase chain reaction. Patients were classified into 2 groups based on the findings at cesarean delivery and histological examination: women with placenta accreta (n = 7) and women without placenta accreta (n = 28). Results: The median MoM (multiples of the median) value of cell-free placental mRNA was significantly higher in patients with placenta accreta than in those without placenta accreta (6.50 vs 2.60; P<0.001. Moreover, cell-free placental mRNA was significantly elevated in patients with placenta increta and percreta than in those with simple accreta. Six false-positive results were found on ultrasound, all from patients without placenta accreta and an insignificant rise in cell-free placental mRNA levels. Conclusion: Measuring cell-free placental mRNA in maternal plasma may increase the accuracy of ultrasound and color Doppler in prenatal prediction of placental invasion in patients with suspected placenta accreta. (C) 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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