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Cytochrome P450 1A-Dependent Activities in Deer, Cattle and Horses
Faculty
Veterinary Medicine
Year:
2010
Type of Publication:
Article
Pages:
561-566
Authors:
Darwish, Wageh Sobhy, Ikenaka, Yoshinori, Ishizuka, Mayumi, Ohno, Marumi, Sakamoto, Kentaro Q, Eldaly, Elsaid Abozeid, Fujita, Shoichi
Journal:
JOURNAL OF VETERINARY MEDICAL SCIENCE JAPAN SOC VET SCI
Volume:
72
Research Area:
Veterinary Sciences
ISSN
ISI:000278344700005
Keywords :
CYP1A1, cytochrome P450, equine, ethoxyresorufin O-deethylase, ungulates
Abstract:
The objective of this study was to investigate and characterize the metabolic activities of CYP1A in deer, cattle and horses in comparison to those of rats using ethoxyresorufin O-deethylation (EROD) and methoxyresorufin O-demethylation (MROD) assays. We performed an inhibition study for these activities using anti-rat CYP1A1 antibody and identified that these activities were due to the CYP1A subfamily. Interspecies differences in the CYP1A-dependent activities were highly observed in this study. In particular, we found that the horse had the highest EROD and MROD activities among the examined animal species. In the kinetic analysis, the horses showed the highest Vmax and catalytic efficiency (Vmax/Km), followed by the cattle, deer and rats.
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